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Publications

Xie XM, Dumas T, Tang L, Brennan T, Reeder T, Thomas W, Klein R, Flores J, O’Hara BF, Heller HC, Franken P.  Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures and early postnatal death in mice. Brain Res 2005, 1052:212-221.

Xie XM, Dumas T, Tang L, Brennan T, Reeder T, Thomas W, Klein R, Flores J, O’Hara BF, Heller HC, Franken P.  Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures and early postnatal death in mice. Brain Res 2005, 1052:212-221.

Quik M, Chen L, Parameswaran N, Xie XM, Langston JW, Sarah E. McCallum SE.  Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in MPTP-lesioned primates. J Neurosci 2006;26: 4681-4689

Xie XM, Crowder TL, Yamanaka, A, Morairty SR, LeWinter RD, Sakurai T, Kilduff TS.  GABAB receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. J Physiol 2006;574.2:399–414. PMCID: PMC1817779

Flores AE, Flores JE, Deshpande H, Picazo JA, Xie XM, Franken P, Heller HC, Grahn DA, O'Hara BF., Pattern recognition of sleep in rodents using piezoelectric signals generated by gross body movements. IEEE Trans Biomed Eng. 2007, 54:225-33.

Xie XM, Van Deusen AL, Vitko I, Barrett PQ, Huynh N, Cheng H, Yang N, Edward Perez-Reyes E. Validation of high throughput screening assays against three subtypes of Cav3 T-type channels using molecular and pharmacologic approaches. Assay and Drug Development Technologies 2007;5.2:191-203. PMID: 17477828

Xie XM, Wisor, J, Hara, J, Crowder, T, LeWinter, R, Khroyan, TV, Yamanaka, A, Diano, S, Horvath, T, Sakurai, T, Lawrence Toll, T. & Kilduff, TS. Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. J Clinical Investigation. 2008;118:2471-24 PMCID2423866

Sonmez K, Zaveri NT, Kerman IA, Burke S, Neal CR, Xie XM, Watson SJ, Toll L. Evolutionary sequence modeling for discovery of peptide hormones. PLoS Comput Biol 2009;5(1): e1000258. PMCID2603333

Hara, J, Gerashchenko, D, Wisor, J, Sakurai, T, Xie XM, Kilduff, T.S.  Thyrotropin-releasing hormone increases behavioural arousal through modulation of hypocretin/orexin neurons. J Neurosci 2009,29(12):3705-14 PMCID: PMCID:2712668

Zhou, W., Madrid, P., Fluitt, A., Andreas Stahl, A.S., and Xie, X.M. Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5. J. Biomolecular Screening 2010, 15(5):488-97. PMCID: PMC2887688

Gerashchenko, D., Horvath, T.L., and Xie, X.M.Direct inhibition of hypocretin/orexin neurons in the lateral hypothalamus by nociceptin/orphanin FQ blocks stress-induced analgesia in rats, Neuropharmacology (2011) 60(4):543-9. PMCID: PMC3031765

Villeda SA, Luo J, Kira I. KI, Zou B, Britschgi M, Stan TM, Bieri G, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XM, Thomas A. Rando TA, and Wyss-Coray T.  The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature (London) 2011; 477:90-94. PMID: 21886162

Xiang, Z. et al., Xie XM, Conn, PJ, Weaver, CD and Lindsley, C.W. The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease. ACS Chemical Neuroscience, 2011, 2 (12): 730–742

Kulkarni*, S., Zou* B.D., Hanson, J., Micci, MA, Tiwari, G., Becker, L., Kaiser, M., Xie XM, and J Pasricha P. J. Gut-derived factors promote neurogenesis of CNS-neural stem cells and nudge their differentiation to an enteric-like neuronal phenotype. Am J Physiology - Gastrointestinal and Liver Physiology. 2011, 301:(4) G644-G655. PMID:21817062,PMCID: PMC3191554

Toll, L, Zaveri, NT, Polgar, W.E, Jiang, F, Khroyan, TV, Zhou, W, Xie, XM, Stauber GB, Matthew R. Costello, MR, Leslie, FM (2012) AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats. Neuropsychopharmacology

Khroyan TV, Zhang J, Yang LY, Zou B, Xie JJ, Pascual C, Malik A, Xie JZ, Zaveri NT, Vazquez J, Polgar W, Toll, L, Fang J and Xie, XMRodent Motor and Neuropsychological Behavior Measured in Home Cages Using the Integrated Modular Platform – SmartCageTM. Clinical and Experimental Pharmacology and Physiology, 2012 ('Accepted Article', doi: 10.1111/j.1440-1681.2012.05719.x)

Vazques-DeRose J, Stauber G, Khroyan TV, Xie XS, Zaveri NT, Toll L. Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity. Eur J Pharmacol 2013 Jan. 15; 699(1-3): 200-6 PMID: 23219985

Xiaoxing Xiong, Robin E. White, Lijun Xu, Liya Yang, Xiaoyun Sun, Bende Zou, Conrado Pascual, TAkeshi Sakurai, Rona G. Giffard and Ximon (Simon) Xie Mitigation of Murine Facal Cerebral Ischemia by the Hypocretin/Orexin System is Associated With Reduced Inflammation. Stroke, 2013; 44:764-770

LIya Yang, Bende Zou, Xiaoxiong Xiaong, Conrado Pascual, James Xie, Adam Malik, Julian Xie, Takeshi Sakurai and Xinmin (Simon) Xie Hypocretin/Orexin Neurons Contribute to Hippocampus-Dependent Social Memory and Synaptic Plasticity in Mice The Journal of Neuroscience, March 20, 2013 33(12):5275-5284

Sarah Srodulski, Savita Sharma, Adam B Bachstetter, Jennifer M Brelsfoard, Conrado Pascual,Xinmin Simon Xie, Kathryn E Saatman, Linda J Van Eldik and Florin Despa Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin Molecular Neurodegeneration, 2014

Narendiran Rajasekaran1, Ricky Tran, Conrado Pascua, Xinmin Xie, Elizabeth D. Mellins Reduced Locomotor Activity Correlates with Increased Severity of Arthritis in a Mouse Model of Antibody-Induced Arthritis* Journal of Rheumatology and Autoimmune Diseases, 2014

Mario A. Saporta a,b,⁎, Vu Dangb, Dmitri Volfsonb, Bende Zou c, Xinmin (Simon) Xie c, Adijat Adebola d, Ronald K. Liem d, Michael Shy a, John T. Dimos b Axonal Charcot–Marie–Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties Experimental Neurology, October 2014

Akihiko Ozawa, Gloria Brunori, Daniela Mercatelli, Jinhua Wu, Andrea Cippitelli, Bende Zou, Xinmin (Simon) Xie, Melissa Williams, Nurulain T. Zaveri, Sarah Low, Gre´gory Scherrer, Brigitte L. Kieffer, and XLawrence Toll1 Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization The Journal of Neuroscience, August 2015

Andrea Cippitelli1*, Jinhua Wu1*, Kelly A Gaiolini1, Daniela Mercatelli1, Jennifer Schoch1, Michelle Gorman1, Alejandra Ramirez1, Roberto Ciccocioppo2, Taline V Khroyan3, Dennis Yasuda4, Nurulain T Zaveri4, Conrado Pascual5, Xinmin (Simon) Xie5 and Lawrence Toll1 AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology British Journal of Pharmacology, November 2014

Jianyu Lua, Angelo Aguilar a, Bende Zou b, Weier Bao a, Serkan Koldas a, Aibin Shi a, John Desper a, Philine Wangemann c, Xinmin Simon Xie b, Duy H. Hua Chemical synthesis of tetracyclic terpenes and evaluation of antagonistic activity on endothelin-A receptors and voltage-gated calcium channels Bioorganic & Medicinal Chemistry, June 2015

Xi Xie, Conrado Pascual, Christopher Lieu, Seajin Oh, Ji Wang, Bende Zou, Julian Xie, Zhaohui Li, James Xie, David C. Yeomans, Mei X. Wu and Xinmin Simon Xie Analgesic Microneedle Patch for Neuropathic Pain Therapy ACS NANO American Chemical Society, December, 2016

 

 

 

Book Chapters

Kilduff TS, Morairty SR, Steininger TL, Xie XM. (2007)  Hypocretin, GABAB receptors and sleep.  In Narcolepsy and Hypersomnia, Bassetti, C, Billiard M, and Mignot E, eds. New York: Marcel Dekker, Inc. pp. 375-386.

Xie XM, Pardi D, Black J. (2007)  Molecular and cellular actions of γ-Hydroxybutyric acid (GHB): Possible mechanisms underlying GHB efficacy in narcolepsy.  In Narcolepsy and Hypersomnia, Bassetti, C, Billiard M, and Mignot E, eds. New York: Marcel Dekker, Inc. pp. 583-620.

Kilduff, T.S., J. Hara, T. Sakurai and X.M. Xie (2011).  Afferent control of the hypocretin/orexin neurons.  In “Narcolepsy: Pathophysiology, Diagnosis, and Treatment”, C.R. Baumann, T.E. Scammell and C. Bassetti, Eds.  New York:  Springer.  pp. 153-162

Xie, X.M,  Zhang, J, Zou, B.D., Xie, J., Fang, J., Zaveri, NT., and Khroyan. TV. (2012) Rodent Behavioral Assessment in the Home Cage Using the SmartCageTM System.  Xu, XM et al., eds. Springer Protocols, Humana Press, Springer, pp. 205-244

Xie, X.M (2015) The Neuronal Circuit Between Nociceptin/Orphanin FQ and Hypocretins/Orexins Coordinately Modulates Stress-Induced Analgesia and Anxiety-Related Behavior. Vitamins and Hormones, Elsevier, pp. 296-316

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