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In vivo pharmacokinetics tests and sample harvest

Model Assay Name Measurements
1.    Wild type mice 1. P.O (e.g., gavage) 1. Drugs or biomarker levels in plasma and key organ tissues (via subcontractors)
2.    Transgenic mice 2. S.C. 2. Histopathology and immunohistochemistry (IHC, via subcontractor)
3.    Cannulated rodents 3. I.P.  
4.    Control 4. I.V.  
5.    Treatment 5. I.T. (intrathecal injection)  
  6. Mini-pump